Faculty & Staff Directory
Costanza Lo Cascio, BSc
Costanza Lo Cascio received her BSc in molecular and cellular biology from the University of Bath in the United Kingdom. During her undergraduate studies, Costanza participated in a professional placement program at Barrow under the guidance of Dr. Shwetal Mehta.
While at Bath, she completed her senior research thesis as a member of Dr. Adele Murrell’s laboratory, where she studied the role of DNA hydroxymethylation in metastatic colorectal cancer. Costanza re-joined the Mehta Laboratory in 2016, and is currently a postdoctoral fellow in the Ivy Brain Tumor Center.
Costanza’s research is focused on identifying OLIG2-specific interactors in glioma stem-like cells, with the aim of elucidating novel ways to target the OLIG2 signaling axis in GBM.
Year Joined: 2016
PI: Shwetal Mehta, PhD
Email: clocasci@asu.edu
Research interest: Understanding the molecular mechanisms that cancer stem cells in malignant brain tumors employ to evade and change cellular fate in response to radiation treatment.
Quisinostat is a brain-penetrant radiosensitizer in glioblastoma
Date: 11/2023
Authors: Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna-Melendez, James B. McNamara, Connor I. White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Claudia Cantoni, Wonsuk Yoo, Nader Sanai, Artak Tovmasyan, Shwetal Mehta
Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single-Cell Resolution using a Microfluidic Tumor Microenvironment Model
Date: 07/2022
Authors: Emmanuela A. Adjei-Sowah, Samantha A. O'Connor, Jaimeson Veldhuizen, Costanza Lo Cascio, Christopher Plaisier, Shwetal Mehta, Mehdi Nikkhah
Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells
Date: 09/2021
Authors: Costanza Lo Cascio, James B. McNamara, Ernesto L. Melendez, Erika M. Lewis, Matthew E. Dufault, Nader Sanai, Christopher L. Plaisier, Shwetal Mehta
Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β Pathway
Date: 06/2017
Authors: Shiv K. Singh, Roberto Fiorelli, Robert Kupp, Sindhu Rajan, Emily Szeto, Costanza Lo Cascio, Cecile L. Maire, Yu Sun, John A. Alberta, Jennifer M. Eschbacher, J. M. Eschbacher, Keith L. Ligon, Michael E. Berens, Nader Sanai, Shwetal Mehta
Costanza Lo Cascio, BSc
Costanza Lo Cascio received her BSc in molecular and cellular biology from the University of Bath in the United Kingdom. During her undergraduate studies, Costanza participated in a professional placement program at Barrow under the guidance of Dr. Shwetal Mehta.
While at Bath, she completed her senior research thesis as a member of Dr. Adele Murrell’s laboratory, where she studied the role of DNA hydroxymethylation in metastatic colorectal cancer. Costanza re-joined the Mehta Laboratory in 2016, and is currently a postdoctoral fellow in the Ivy Brain Tumor Center.
Costanza’s research is focused on identifying OLIG2-specific interactors in glioma stem-like cells, with the aim of elucidating novel ways to target the OLIG2 signaling axis in GBM.
Year Joined: 2016
PI: Shwetal Mehta, PhD
Email: clocasci@asu.edu
Research interest: Understanding the molecular mechanisms that cancer stem cells in malignant brain tumors employ to evade and change cellular fate in response to radiation treatment.
Quisinostat is a brain-penetrant radiosensitizer in glioblastoma
Date: 11/2023
Authors: Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna-Melendez, James B. McNamara, Connor I. White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Claudia Cantoni, Wonsuk Yoo, Nader Sanai, Artak Tovmasyan, Shwetal Mehta
Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single-Cell Resolution using a Microfluidic Tumor Microenvironment Model
Date: 07/2022
Authors: Emmanuela A. Adjei-Sowah, Samantha A. O'Connor, Jaimeson Veldhuizen, Costanza Lo Cascio, Christopher Plaisier, Shwetal Mehta, Mehdi Nikkhah
Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells
Date: 09/2021
Authors: Costanza Lo Cascio, James B. McNamara, Ernesto L. Melendez, Erika M. Lewis, Matthew E. Dufault, Nader Sanai, Christopher L. Plaisier, Shwetal Mehta
Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β Pathway
Date: 06/2017
Authors: Shiv K. Singh, Roberto Fiorelli, Robert Kupp, Sindhu Rajan, Emily Szeto, Costanza Lo Cascio, Cecile L. Maire, Yu Sun, John A. Alberta, Jennifer M. Eschbacher, J. M. Eschbacher, Keith L. Ligon, Michael E. Berens, Nader Sanai, Shwetal Mehta